G1-S Phase of the Cell Cycle
| PAG Title | G1-S Phase of the Cell Cycle |
| PAG ID | WIG001816 |
| Type | P |
| Source Link |  Spike |
| Publication Reference | NA |
| PAG Description | The core engines that drive the progression through the eukaryotic cell cycle are complexes of cyclins and cyclin dependent kinases. Cdk4-Cyclin D complex is implicated in committing a cell to the G1/S phase transition, Cdk2-Cyclin E in the initiation of S phase and Cdk2-Cyclin A in its completion as well as in S phase exit. CDKN1A that is activated by various kinds of damages to the cell, interact physically with the latter two aforementioned complexes, and inhibit the cell cycle progression. The E2F1-3 protein family members are the major transcription factors (TFs) that regulates the transcription of genes involved in the cell progression from G1 to the S phase. |
| Species | Homo sapiens |
| Quality Metric Scores | nCoCo Score: 10,047 |
| Information Content | Rich |
| Other IDs | SPIKE00001 |
| Base PAG ID | WIG001816 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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